dMyc Transforms Cells into Super-Competitors

dMyc Transforms Cells into Super-Competitors

Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of Myc protein are apposed and show that this invariably elicits a win/lose situation reminiscent o...

02-P008 Epithelial cells of Drosophila turn super-competitors during tumor progression

multifunctional regulatory nuclear compartment that, besides hosting ribosome biogenesis, regulates cellular growth, cell death, and the cell cycle. The Myc transcription factor stimulates tissue growth, in part by activating the expression of genes required for ribosome biogenesis. By qRT-PCR we show that Myc is necessary and sufficient for transcriptional activation of vito expression. Our re...

Hybrid medical leadership turns competitors into collaborators.

Airway epithelial IL-15 transforms monocytes into dendritic cells.

IL-15 has recently been shown to induce the differentiation of functional dendritic cells (DCs) from human peripheral blood monocytes. Since DCs lay in close proximity to epithelial cells in the airway mucosa, we investigated whether airway epithelial cells release IL-15 in response to inflammatory stimuli and thereby induce differentiation and maturation of DCs. Alveolar (A549) and bronchial (...

Turning single cells into microarrays by super-resolution barcoding.

In this review, we discuss a strategy to bring genomics and proteomics into single cells by super-resolution microscopy. The basis for this new approach are the following: given the 10 nm resolution of a super-resolution microscope and a typical cell with a size of (10 µm)(3), individual cells contain effectively 10(9) super-resolution pixels or bits of information. Most eukaryotic cells have 1...